New England Stem Cell Institute

Stem Cell Clinic & Regenerative Medicine located in Glastonbury, CT

Prolotherapy can be considered the original regenerative medicine treatment, first developed to treat ongoing painful musculoskeletal conditions. At New England Stem Cell Institute, Paul Tortland, DO, and Jeffrey LaVallee, MD, have been using prolotherapy to reduce pain and promote healing since 1995, longer than most medical practices in the United States. To learn more about prolotherapy and how it might help you, call the Glastonbury, Connecticut, office today or request an appointment online.

Prolotherapy Q & A



What is prolotherapy? 

At the New England Stem Cell Institute, we’ve been performing prolotherapy since 1995, longer than most practices in the country.

Sometimes referred to as “proliferative therapy,” Prolotherapy is a form of regenerative medicine that stimulates your body’s natural healing powers. The treatment involves an injection made up of dextrose (a type of sugar) and Novocaine™. The sugar in the injection mildly irritates your tissue, which tricks your body into thinking it’s been injured. This then signals your body to send healing cells to repair the damage. 

Prolotherapy was invented in the 1950s by Ohio surgeon George Hackett MD.  He used it successfully to treat chronic back pain. In one sense, prolotherapy may be considered the “original” regenerative medicine treatment. 

Prolotherapy stimulates repair of damaged tissue and production of new tissue.  It does NOT cause scar tissue formation. 

What is Prolozone®? 

Prolozone is a variant of prolotherapy.  Invented by regenerative medicine and anti-aging physician Frank Shallenberger MD, Prolozone modifies the basic prolotherapy dextrose-Novocaine solution by adding various vitamins and homeopathic ingredients that can help provide nutrition for the cells during healing. 

In addition, Prolozone also involves injecting the damaged area with a mixture of oxygen and ozone gases immediately after the liquid solution is injected.  Oxygen and ozone also support cell function to stimulate healing. 

What conditions benefit from prolotherapy and Prolozone? 

The team at the New England Stem Cell Institute offers prolotherapy as a treatment to manage many common musculoskeletal conditions. Some of the conditions that can benefit from prolotherapy include: 

  • Rotator cuff injuries
  • Tennis and golfer’s elbow
  • Arthritis
  • Chronic sprains and strains
  • Chronic tendinitis
  • Chronic neck and back pain 

Because the injection contains an anesthetic and all-natural ingredients, prolotherapy and Prolozone are considered very safe treatments with minimal side effects or risks. 

Am I a good candidate for prolotherapy or Prolozone? 

Your physician at the New England Stem Cell Institute will discuss with you whether Prolotherapy or Prolozone is the best treatment option for you. 

Why would I have Prolotherapy or Prolozone instead of PRP or Stem Cells? 

First, prolotherapy and Prolozone don’t require drawing blood or harvesting stem cells from bone marrow or fat.  So treatments are much quicker and don’t require more invasive harvesting techniques. And treatments are less expensive since no cells need to be obtained.

Also, prolotherapy and Prolozone generally are slightly milder or less aggressive treatments than either PRP or stem cell-based treatments.  For patients where a less robust treatment is needed, prolotherapy or Prolozone may be more appropriate.   

However, because there are less robust treatments, typically more treatments are needed.  In our experience at the New England Stem Cell Institute, one PRP treatment is roughly equivalent to 2-3 prolotherapy or Prolozone treatments.